2nd
Spring Pharmaceutical Synchrotron X-Ray Powder Diffraction Workshop
9th - 12th May 2019
PSI Auditorium
The SPS-XRPD-2 workshop in 2019 was conducted in conjunction with the 16th Pharmaceutical Powder X-ray Diffraction (PPXRD-16) Symposium and was hosted at the Paul Scherrer Institute in Switzerland from May 9th to May 12th, 2019.
The organizing committee for this collaborative event included representatives from Excelsus Structural Solutions, Purdue University, Argonne National Laboratory, Improved Pharma, Park Innovaare, Paul Scherrer Institute, and the International Center for Diffraction Data (ICDD).
The technical program for PPXRD-16 & SPS-XRPD-2 commenced on Thursday, May 9th, featuring a half-day workshop on the advantages and disadvantages of Laboratory and Synchrotron XRPD. The program continued throughout Friday to Sunday with a series of technical sessions, concluding at 4:40 pm on Sunday, May 12th, followed by closing remarks.
The event commenced with a preliminary one-day workshop dedicated to exploring the advantages and disadvantages of Laboratory and Synchrotron XRPD.
DAY 1 - 9TH MAY 2019
| 8:30 am – 4:30 pm | Half-day workshop on Laboratory and Synchrotron XRPD – Advantages and Disadvantages 8:30 Phil Willmott: “Synchrotron Radiation and SR based techniques”
10:00 Tom Blanton: “Laboratory X-ray Powder Diffraction and the Power of Crystallographic Database”
1:30 Tour: Visit PSI Large Scale Facilities |
| 4:30 pm – 5:00 pm | Welcome to our Attendees |
| 5:00 pm - 6:00 pm | Opening Plenary: Industry Speaks to Academia Invited presentation by Arnaud Grandeury, Novartis Pharma, Switzerland |
| 6:00 pm - 7:30 pm | Welcoming Reception Please join us after the Plenary for light refreshments and cocktails. |
DAY 2 - 10TH MAY 2019
| 8:30 am - 9:10 am |
P25 Patenting Solid Forms: A Review of US Case Law Involving Dr. Joel Bernstein Jill MacAlpine, Finnegan, USA |
| 9:10 am – 9:50 am | P26 Facts and Fictions about Polymorphism: Personal Recollections of our Good Friend, Joel Bernstein Susan M. Reutzel-Edens, Eli Lilly and Company, USA |
| 9:50 am - 10:30 am | P24 Solid Form Patents in Pharmaceutical Development Eyal Barash, Barash Law LLC, USA |
| 10:30 am – 11:00 am | Coffee break |
| 11:00 am – 11:40 am | P37 Invited – Role of Physical Form of the Active Pharmaceutical Ingredient (API) and Excipients Raj Suryanarayanan, University of Minnesota, USA |
| 11:40 am - 12:10 pm | P5 High-Throughput Quantum Molecular Dynamics Constrained by Electron Diffraction Aimed at the Prediction of Amorphous Solid Dispersion Stability Georgios Antipas, Molecular Modelling Laboratory (MML), Switzerland |
| 12:10 pm – 1:15 pm | Lunch |
| 1:15 pm – 1:55 pm | P11 Invited – The Direct Derivation (DD) Method for Quantitative Phase Analysis: A Practical Approach with the Direct-fitting of Observed Diffraction Patterns Hideo Toraya, Rigaku Corporation, Japan |
| 1:55 pm - 2:25 pm | P8 Method Validation for Quantitative Determination of the (Pseudo) Polymorphs Ratio in DS and DP Samples: Performance and Compliance Matteo Daldosso*, Silvia Lenzini, Brigida Allieri, Aptuit, an Evotec Company, Italy Sarah Le Meur, Michel Wagneur, Luc Aerts, UCB Pharma, Belgium |
| 2:25 pm - 2:55 pm | P10 Using Portable X-ray Diffraction (XRD) with Pseudo-Thin-Film Type Analysis for API Verification and Counterfeit Formulation Investigations Jose Brum, Olympus OSSA, USA |
| 2:55 pm – 3:30 pm | Coffee Break |
| 3:30 pm - 4:10 pm | P28 Invited – Overview of Synchrotron X-ray Powder Diffraction: Instruments and Case Studies Peter Stephens, Stony Brook University, USA |
| 4:10 pm - 4:30pm | P36 Industrial Collaboration: How to make it happen at the Swiss Light Source? Stefan Müller, Paul Scherrer Institut & SLS Techno Trans AG, Switzerland |
| 4:30 pm - 5:10 pm | P39 Invited – Time and Matter: The Material Science Beamline at the SLS Nicola Casati, Paul Scherrer Institute, Switzerland |
| 5:10 pm - 5:40 pm | P35 – ID22 High Resolution Powder Diffraction Beamline at ESRF Andy Fitch, ESRF, France |
| From 7:30 pm |
Conference Dinner |
DAY 3 - 11TH MAY 2019
| 9:00 am - 9:56 am |
9:00 P15 Humidity Effects on Amorphous Pharmaceuticals C.J. Benmore*, Argonne National Laboratory, USA P. Smith, S.R. Byrn, Improved Pharma, USA J.K.R. Weber, Argonne National Laboratory and Materials Development, Inc., USA 9:08 P18 Quantification of Multiple Amorphous and Crystalline Phases Maria Orlova*, PANalytical B.V., Switzerland Detlef Beckers, Thomas Degen, PANalytical B.V., The Netherlands 9:16 P22 Computed Tomography Analysis for Process Development and Quality Control of Formulations Detlef Beckers*, Natalia Dadivanyan, Detlev J. Götz, Malvern Panalytical B.V. 9:24 P23 Atomic Pair Distribution Function (PDF) and X-ray Scattering Methods to Assess Amorphous Organic Compounds Detlef Beckers*, Milen Gateshki, Malvern Panalytical B.V., The Netherlands 9:32 P27 Use of “Cleaning” Algorithm for Model-Free Correction of Instrumental Aberrations in XRPD Patterns Vladimir Kogan*, Dannalab, The Netherlands Detlef Beckers, Alexander Kharchenko, Malvern Panalytical B.V., Almelo, The Netherlands 9:40 P31 Total Pattern Analyses of Pharmaceutical Formulations T.G. Fawcett, S. Gates-Rector, M. Rost, A.M. Gindhart, T.N. Blanton*, S.N. Kabekkodu, ICDD, USA 9:48 P34 Attempts and Approximations for a Background Modeling in Pharmaceutical Samples in Patterns of XRD and S-XRPD Bárbara A. Ramírez Almaguer*, Lauro Bucio, Universidad Nacional Autónoma de México, México Mathilde Reinle-Schmitt, Mickael Morin, Fabia Gozzo, Excelsus Structural Solutions, Switzerland Antonio Cervellino, Paul Scherrer Institute, Switzerland |
| 9:56 am – 10:30 am | Coffee break |
| 10:30 am – 11:10 am | P20 Invited–Magnifying Nano-/Meso- Structural Information of Amorphous Pharmaceutical Solids through Small Angle X-Ray Scattering Amrit Paudel*, Peter Laggner, Graz University of Technology and Research Center Pharmaceutical Engineering GmbH (RCPE), Austria |
| 11:10 am - 11:50 pm | P14 Invited–SAXS-WAXS Studies of Amorphous, Mesoporous and Nanomaterials C.J. Benmore*, D. Robinson, G. Jennings, J. Ilavsky, S. Shastri, Argonne National Laboratory, USA O.L.G. Alderman, A. Tamalonis, E. Clark, Materials Development Inc., USA E. Soignard, J.L. Yarger, Arizona State University, USA J.K.R. Weber, Argonne National Laboratory and Materials Development, Inc., USA |
| 11:50 am - 12:30 pm | P40 Invited–Understanding the Disordered State of Matter in Pharmaceutical Development Vishal Koradia, Novartis Pharma AG, Switzerland |
| 12:30 pm – 2:00 pm | Lunch |
| 2:00 pm – 2:40 pm | P33 Invited–Macromolecular Powder Diffraction: Ready for Genuine Biological Problems Irene Margiolaki, University of Patras, Greece |
| 2:40 pm - 3:10 pm | P13 Characterizing Proteins Using XRPD and SAXS Techniques on a Laboratory Diffractometer N. Dadivanyan*, J. Bolze, D. Beckers, G. Nénert, T. Degen, Malvern Panalytical B.V., The Netherlands S. Trampari, Kapodistrian University of Athens, Greece S. Logotheti, A. Valmas, S. Saslis, F. Karavassili, I. Margiolaki, University of Patras, Greece |
| 3:10 pm – 3:30 pm | Coffee Break |
| 3:30 pm - 5:30 pm | Guidelines Discussion |
DAY 4 - 12TH MAY 2019
| 8:30 am - 9:10 am |
P29 Invited- How Many Ritonavir Cases are Still Out There? Marcus A. Neumann*, Jacco van de Streek, Hanno Dietrich, Kiran Sasikumar, Asbjörn Burow, Avant-garde Materials Simulation Deutschland GmbH, Germany |
| 9:10 am – 9:40 am | P9 ICDD® Polymer Diffraction Data Project – 100+ PDF® Entries and Growing Tom Blanton, Megan Rost, Stacy Gates-Rector, ICDD, USA |
| 9:40 am – 10:10 am | Coffee Break |
| 10:10 am - 10:50 pm | P7 Invited – Crystal Structures of Large-Volume Commercial Pharmaceuticals Jim Kaduk, North Central College, Illinois Institute of Tech. and Poly Crystallography Inc., USA |
| 10:50 am - 11:30 am | P32 Invited – Structure Determination of Organic Materials from Powder X-ray Diffraction Data: Opportunities for Multi-technique Synergy Kenneth Harris, Cardiff University, United Kingdom |
| 11:30 am - 12:10 pm | P30 Invited – Walking the Tightrope of Complexity – Assessing Probability of Success of Structure Solution from Powder Diffraction Data Pamela Whitfield*, Michael Morin, Mathilde Reinle-Schmitt, Fabia Gozzo, Excelsus Structural Solutions, Switzerland and Belgium |
| 12:10 pm - 12:40 pm | P19 Structure Determination of Nanocrystalline Organic Compounds from Unindexed Powder Data by Real-Space and PDF methods Martin U. Schmidt*, Stefan Habermehl, Carina Schlesinger, Dragica Prill, Goethe University, Germany |
| 12:40 pm – 2:00 pm | Lunch |
| 2:00 pm – 2:40 pm | P17 Invited – Micro to Nanometer Scale Characterization of Pharmaceutical Compounds by Electron Microscopy Partha Pratim Das*, Alejandro Gómez Pérez, Stavros Nicolopoulos, NanoMEGAS SPRL, Belgium |
| 2:40 pm - 3:10 pm | P6 Extensive Polymorph Screening of the Nucleobase Adenine Dubravka Sisak Jung*, DECTRIS, Switzerland Ivan Halasz, Institute Rudjer Boskovic, Croatia Graeme Day, David McDonagh, University of Southampton, UK |
| 3:10 pm - 3:40 pm | P21 Study Real Time Crystallization Process in Organic Crystals using Liquid Cell Transmission Electron Microscopy and Electron Crystallography Techniques on PDIs Alejandro Gomez-Perez*, Partha Pratim Das, Stavros Nicolopoulos, NanoMEGAS, Belgium Yael Tsarfati, Boris Rybtchinski, Weizmann Institute of Science, Israel |
| 3:40 pm - 4:10 pm | P38 Non-Standard Crystallization Methods of API´s & Electron Diffraction: The Future Gustavo Santiso-Quiñones, Crystallise! AG, Switzerland |
| 4:10 pm - 4:30 pm | Closing Remarks |
Feedback
I’m very glad to attend this workshop. Excellent speakers and talks, fruitful discussions! It’s great to see some old friends and make some new. Thank you very much for organizing this wonderful workshop!
Tony Hu, NYU Department of Chemistry
It has been an incredible experience, as a student it brings you the opportunity to meet the experts, share your work and even discuss it
Barbara Ramirez, UNAM Mexico
I was pleasantly surprised that a gathering of highly qualified experts would make their presentations accessible for non-experts without compromising the depth of the subjects addressed
Arturo Araque, Excelsus Scientific Engineering
I was honored to join the SPS-XRPD workshop, hosted by Purdue University, Excelsus Structural Solutions, APS, and Improved Pharma. This collaborative event united industry leaders and synchrotron experts, fostering insightful discussions on Pharma R&D challenges and the benefits of Synchrotron-XRPD analysis. It's crucial for promoting awareness of synchrotron radiation's analytical prowess in pharmaceutical research. Excited for future workshops!
Gabriel L.B. Araujo, Associate Professor, School of Pharmaceutical Sciences, University of São Paulo, Brazil
Very informative and useful to apply the information in my daily professional life’
Naveen K. Thakral, Upsher Smith Laboratories LLC
An excellent mix of theory and practice and a great insight into how pharmaceutical research benefits from x-ray methods
Anonymous
I had the opportunity to interact with and listen to the experts in the field and emerging techniques in XRD and data analysis
Anonymous
An excellent mix of x-ray synchrotron experts and pharma researchers
Anonymous
The 1st SPS-XRPD workshop is a great success. The two-and-a-half workshop assembled x-ray experts from academia, industry and national labs. It is educational, informative and fun. A must-go event for all pharmaceutical scientists
Chenyang Shi, AbbVie Inc
